Hirudin

Common name: Hirudin
Specification: 200ATU/G
300ATU/G
500ATU/G
800ATU/G
Appearance: Brown yellow to brown red powder
Raw Material Source: Leeches
Origin: China
Test Method: Chinese Pharmacopoeia 2020
Package: 1kg/bag
Lead Time: 5 days after payment
Payment: T/T, Western Union
Storage: Store in original tightly closed package from moisture and sunlight

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A Natural Antithrombin—Hirudin

Hirudin is a naturally occurring peptide that is derived from the salivary glands of medicinal leeches. It is widely recognized for its potent anticoagulant properties. The main function of hirudin is to inhibit thrombin, it is an enzyme involved in blood clotting. By binding to thrombin directly, hirudin prevents its interaction with fibrinogen, thereby preventing the formation of fibrin, a critical component of blood clots. This function mechanism makes hirudin an extremely effective as anticoagulant. So hirudin has various application in medicine. It has been utilized in cardiovascular procedures, such as angioplasty and coronary artery bypass grafting, to prevent unwanted blood clotting during surgery. Hirudin is also applied in the treatment of thrombotic disorders, such as deep vein thrombosis and pulmonary embolism, where it helps dissolve existing blood clots and prevent further clot formation. Hirudin offers a natural alternative to traditional drugs like heparin. In addition to its anticoagulant effects, hirudin possesses anti-inflammatory and vasodilatory properties. These properties contribute to its potential therapeutic applications in conditions such as ischemia-reperfusion injury, arterial thrombosis, and microvascular disorders.

The comparison between Hirudin and Heparin

Features Hirudin Heparin
Source Medicinal leeches Synthetics
Mechanism of action Directly inhibits thrombin Enhances activity of antithrombin III
Anticoagulant effect Highly specific, effectively  prevents clot formation Broad-spectrum anticoagulation, inhibits multiple clotting factors
Administration route Injection Injection or intravenous infusion
Side effects (bleeding) Lower risk May cause bleeding
Risk of thrombocytopenia Low risk High risk

The application of Hirudin

Medical field: Hirudin is used as an anticoagulant in specific clinical situations. It has been used in cardiac surgeries to prevent clot formation and maintain blood flow. Additionally, Hirudin is valuable in cases where patients have developed heparin-induced thrombocytopenia.
Dietary supplements: It is believed to have antioxidant and anti-inflammatory properties, the dietary supplement contain Hirudin may help to body health.
Pharmaceutical Industry: Hirudin has been studied for its potential use in developing therapeutic medications. Its ability to inhibit thrombin has attracted attention in developing drugs for thrombotic disorders and other clotting-related conditions.

Natural Hirudin Application Prospect

Hirudin is a promising anticoagulant and stasis-removing drug, it can be used to treat various thrombotic diseases, especially venous thrombosis and disseminated intravascular coagulation. It also can be used to prevent arterial thrombosis after surgery, prevent thrombi after thrombolysis or revascularization. In microsurgery, failure is often caused by a vascular embolism at the anastomosis. The use of Hirudin extract can promote wound healing. Studies have shown that hirudin also plays a role in tumor treatment, it can prevent the metastasis of tumor cells. It is effective in fibrosarcoma, osteosarcoma, angiosarcoma, melanoma, lymphoma and leukemia cells. Clinical studies have shown that intravenous and subcutaneous injection of Hirudin has no obvious side effects. No matter acute or subacute toxicity tests, it does not affect on blood pressure, heart rate, blood phase, bleeding time and blood chemical composition, and respiratory system Influence. No allergic reaction, generally no specific antibody found. In addition, Hirudin can be taken orally, it brings great convenience to patients. Hirudin is relatively stable, trypsin does not destroy its activity, and some hydrolyzed fragments of Hirudin still have the effect of inhibiting thrombin.

COSMETICS

The cosmetics market is turning to natural ingredients now. Consumers are more concerned about the effects brought by healthy ingredients. How to reduce the risk of skin irritation and allergies caused by synthetic ingredients. Natural ingredients have become the best alternative. Research and demand for natural ingredients have become the most urgent revolution in this market.

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FUNCTION FOOD

Humans in the 21st century need a healthier dietary structure to adapt to new needs characterized by a lifestyle. A more reasonable dietary structure and more balanced nutrition provide all the nutrients necessary for a healthy life. Functional foods are quickly filling consumers’ cupboards and refrigerators.

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PHARMACEUTICALS

The pharmaceutical industry demands active, natural ingredients to develop plant-based medicines, as well as highly purified natural molecules for use as starting materials for synthetic active pharmaceutical ingredients. These highly pure natural compounds can also be used in the development of new drugs.

At GoFine, we are professional in the complex process involved in developing these kinds of products, and we avail our expertise, advanced R&D, and standardized production to provide you with customized solutions to meet your needs.

NUTRACEUTICALS & DIETARY SUPPLEMENTS

The nutraceutical and dietary supplement market has undergone tremendous growth in the past 20 years, calling the companies to have a high degree of innovation, more efficient supply, greater flexibility, and more comprehensive services to adapt to market changes.

At GoFine, we work in close collaboration with you to develop innovative natural extracts with a robust scientific foundation. Not only will we provide the natural ingredients, but also we help you conduct preliminary studies of both the market and your competition, develop and formulate the finished products, and integrate the innovative natural ingredients, all the way to manufacturing the final product.